Kynurenine Pathway and Related Neurodegenerative Disorders
نویسندگان
چکیده
منابع مشابه
The kynurenine pathway and neurodegenerative disease.
Neuroactive metabolites of the kynurenine pathway (KP) of tryptophan degradation have been closely linked to the pathogenesis of several neurodegenerative diseases. Tryptophan is an essential amino acid required for protein synthesis, and in higher eukaryotes is also converted into the key neurotransmitters serotonin and tryptamine. However, in mammals >95% of tryptophan is metabolized through ...
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The kynurenine pathway represents a major route for the catabolism of tryptophan (TRP). In the body, TRP is transported around the periphery either bound to albumin (90%) or in free form (10%), the two states existing in equilibrium (McMenamy 1965). However, only free form TRP can be transported across the blood-brain barrier (BBB) by the competitive and nonspecific L-type amino acid transporte...
متن کاملB vitamins and berries and age-related neurodegenerative disorders.
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ژورنال
عنوان ژورنال: Turkiye Klinikleri Journal of Neurology
سال: 2018
ISSN: 1304-0537,2146-8907
DOI: 10.5336/neuro.2018-60154